But its successor from Nintendo, the Wii U, hasn't gone down as well with gamers.
"Maybe the Wii U hasn't been quite as successful as Wii but Nintendo keeps going from strength to strength," Nintendo's James Honeywell told Newsbeat.
"Nintendo is willing to take those risks, which is why it's such a vibrant and interesting company," he said.
Nintendo is arguably the most famous gaming company in the world with 100 years' worth of experience in making games (the firm's founder started off with playing cards).
In their video games, characters like Mario, Zelda and Yoshi have captured hearts and minds across the globe.
But since this generation of consoles hit the shelves, fewer gamers have been deciding to part their cash on the console that those characters call home.
Instead, the lure of playing games like Grand Theft Auto, Call of Duty and Destiny on other consoles has been more appealing to most gamers.
Gaming writer and presenter Dan Maher explained: "Riding high on the crest of the wave of the Wii, Nintendo tried to copy the same formulae with the Wii U and create a kind of dual screen experience."
"The concept was sound in theory but people really struggled to latch onto it, and consumers and developers didn't really latch on to it."
"In terms of the home console market, they are being absolutely trounced by Xbox One and PS4," he added.
Most of the Wii U's games are made in-house because lots of third party game developers have decided to stop supporting the console.
So no Call of Duty Black Ops 3, Assassin's Creed Syndicate or Fallout 4 for Wii U owners.
The makers of role playing game Skylanders SuperChargers, however, are bucking that trend by continuing to work with Nintendo to create content for the Wii U.
Karthik Bala, CEO at Vicarious Visions, who make Skylanders SuperChargers, told Newsbeat: "We've had a relationship with Nintendo for years.
"We have very similar philosophies and to be able to collaborate with those creators has been a phenomenal experience."
Nintendo's James Honeywell added: "We're a constantly innovating company.
"We've got some key announcements coming next year and I think we've already started to talk about future consoles and moving our content on to smart devices.
"Plus obviously we have the games here that you can get in a few months' time.